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Dihydroberberine
Description
Dihydroberberine, a hydrogenated derivative of Berberine (BBR), exerts anti-inflammatory effect via dual modulation of NF-κB and MAPK signaling pathways.
Molecular Formula
C20H19NO4
IUPAC Name
16,17-Dimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(21),2,4(8),9,15(20),16,18-heptaene
Stability
The product is stable for two years when stored at the recommended temperature.
Purity
Ligand-based Virtual Screening (LBVS)
LBVS methods use compound information to predict activity, which measure the similarity of the compounds in the library to reference compounds that are active towards a target of interest. 2D or 3D chemical structures or molecular descriptors of the known actives are used to retrieve other (‘similar”) compounds of interest in a database using different types of similarity measures or by seeking a common substructure or pharmacophore between the query molecules and the scanned libraries. LBVS has the significant advantages over other virtual screening approaches because it does not involve macromolecules in the calculations and requires no prior knowledge of active ligands. It is chosen as one of the most popular approaches for drug discovery and lead optimization especially when three-dimensional structures of potential drug targets are not available.
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The types of snakes that foxes eat varies depending on their geographic location. In North America, red foxes have been observed eating a variety of snake species, including garter snakes, rat snakes, and even venomous snakes such as copperheads and rattlesnakes.
Do Foxes Eat Snakes https://animaliaplanet.com/do-foxes-eat-snakes/? Foxes love to eat snakes, whether they’re actively hunting them down or coming across a carcass and finishing it off. Foxes will eat anything ranging from fruit and seeds to birds and, you guessed it, snakes. Although they aren’t the main dish for every meal, foxes are very fond of eating snakes!
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A Guide to the Surgical Vascular Tunneler: Your Essential Vascular Tunneler Kit
Introduction:
In the field of medicine, surgical procedures often require precise and delicate techniques. One such tool that aids surgeons in performing vascular surgeries is the Surgical Vascular Tunneler. In this article, we will explore what a Vascular Tunneler is, its components, how it works, and its importance in surgical procedures. Whether you're a medical professional or an individual seeking information, this guide aims to provide a comprehensive overview of the Vascular Tunneler and its relevance.
What is a Surgical Vascular Tunneler?
A Surgical Vascular Tunneler is a specialized tool used in surgical procedures involving blood vessels. It is designed to create tunnels under the skin, allowing the passage of various medical devices, such as catheters or wires, through blood vessels. The Vascular Tunneler facilitates the process of accessing and treating specific areas within the vascular system.
Components of a Vascular Tunneler Kit:
A typical Vascular Tunneler Kit consists of the following components:
Vascular Tunneler: The main tool used to create the tunnels.
Dilator: A tapered instrument that widens the tunnel created by the Vascular Tunneler, allowing for the insertion of medical devices.
Sutures: Threads used to secure the blood vessels after the procedure.
Sterile drapes and gauze: Used to maintain a sterile field during the surgery.
Local anesthetic: Numbs the area where the tunneling will occur, ensuring patient comfort.
How Does a Vascular Tunneler Work?
The Vascular Tunneler is carefully inserted beneath the skin, near the target blood vessel. With gentle pressure, it creates a pathway, or tunnel, for the medical device to travel through. The dilator is then used to widen the tunnel, providing enough space for the device to pass smoothly. The surgeon can guide the medical device through the tunnel and into the blood vessel, allowing for necessary treatments or interventions.
Benefits and Importance of a Vascular Tunneler:
The use of a Vascular Tunneler offers several benefits and plays a crucial role in surgical procedures:
Precision: The Vascular Tunneler enables surgeons to create accurate and controlled tunnels, reducing the risk of injury to surrounding tissues.
Minimally Invasive: By using tunnels instead of large incisions, vascular surgeries can be less invasive, resulting in reduced scarring and faster recovery times for patients.
Versatility: Vascular Tunnelers can be used in various procedures, such as angioplasty, stenting, or catheter insertion, making them an essential tool for vascular surgeons.
Common Surgical Procedures that Utilize a Vascular Tunneler:
Vascular Tunnelers are frequently used in the following surgical procedures:
Angioplasty: Inflating a balloon to widen narrowed or blocked blood vessels.
Stenting: Inserting a mesh-like tube to keep a blood vessel open.
Central Venous Catheter Insertion: Placing a catheter into a large vein for long-term medication administration or dialysis.
Arteriovenous Fistula Creation: Connecting an artery and vein for hemodialysis access.
Frequently Asked Questions about Vascular Tunneler Kits:
Q1: Are Vascular Tunnelers reusable?
A: No, Vascular Tunnelers are typically single-use devices to ensure sterility and prevent cross-contamination.
Q2: How much does a Vascular Tunneler Kit cost?
A: The cost of a Vascular Tunneler Kit varies depending on the brand, specifications, and supplier. It is advisable to consult medical supply companies or healthcare providers for pricing information.
Q3: Can I purchase a Vascular Tunneler Kit if I have a limited budget?
A: If you have a limited income, it is recommended to reach out to local healthcare providers, clinics, or charitable organizations that may provide assistance or resources for medical equipment.
Conclusion:
The Surgical Vascular Tunneler is an indispensable tool in vascular surgery, enabling surgeons to perform intricate procedures with precision and minimal invasiveness. Its role in creating tunnels for medical devices within the vascular system helps improve patient outcomes and promotes faster recovery. If you require a Vascular Tunneler Kit, it is best to consult healthcare providers or explore assistance options in your community to address any financial limitations. Remember, proper medical guidance and professional support are crucial when considering any surgical procedure.