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In contrast, there are no official guidelines for the intake of long-chain omega-3s. Yet, health organizations generally recommend a minimum of 250 mg and a maximum of 4,000 mg — and no more than 5,000 mg — of combined EPA and DHA per day, unless instructed otherwise by a health professional. Omega-3 supplements have many potential benefits for your cardiovascular health. One key benefit is that they help lower your triglyceride levels. Too many triglycerides in your blood (hypertriglyceridemia) raises your risk of atherosclerosis, and through this, can increase your risk of heart disease and stroke.